BiopestPeptidV1, Main, Exploration, bibRecord, 001068

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.

Identifieur interne : 001068 ( Main/Exploration ); précédent : 001067; suivant : 001069

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.

Auteurs : Jong Ho Park [Corée du Sud] ; Seung Wook Yang [Corée du Sud] ; Jung Mi Park [Corée du Sud] ; Seung Hyeun Ka [Corée du Sud] ; Ji-Hoon Kim [Corée du Sud] ; Young-Yun Kong [Corée du Sud] ; Young Joo Jeon [Corée du Sud] ; Jae Hong Seol [Corée du Sud] ; Chin Ha Chung [Corée du Sud]

Source :

Nature communications [ 2041-1723 ] ; 2016.

RBID : pubmed:27545325

Descripteurs français

KwdFr :
- Acétylation (MeSH), Altération de l'ADN (effets des médicaments et des substances chimiques), Altération de l'ADN (effets des radiations), Altération de l'ADN (génétique), Carcinogenèse (anatomopathologie), Carcinogenèse (génétique), Cytokines (génétique), Cytokines (métabolisme), Doxorubicine (pharmacologie), Humains (MeSH), Inhibiteur p21 de kinase cycline-dépendante (métabolisme), Lignée cellulaire tumorale (MeSH), Phosphorylation (MeSH), Prolifération cellulaire (génétique), Protéine Bax (métabolisme), Protéine p53 suppresseur de tumeur (métabolisme), Rayons ultraviolets (effets indésirables), Régions promotrices (génétique) (génétique), Ubiquitin-activating enzymes (métabolisme), Ubiquitin-conjugating enzymes (métabolisme), Ubiquitines (génétique), Ubiquitines (métabolisme).
MESH :
- anatomopathologie : Carcinogenèse.
- effets des médicaments et des substances chimiques : Altération de l'ADN.
- effets des radiations : Altération de l'ADN.
- effets indésirables : Rayons ultraviolets.
- génétique : Altération de l'ADN, Carcinogenèse, Cytokines, Prolifération cellulaire, Régions promotrices (génétique), Ubiquitines.
- métabolisme : Cytokines, Inhibiteur p21 de kinase cycline-dépendante, Protéine Bax, Protéine p53 suppresseur de tumeur, Ubiquitin-activating enzymes, Ubiquitin-conjugating enzymes, Ubiquitines.
- pharmacologie : Doxorubicine.
- Acétylation, Humains, Lignée cellulaire tumorale, Phosphorylation.

English descriptors

KwdEn :
- Acetylation (MeSH), Carcinogenesis (genetics), Carcinogenesis (pathology), Cell Line, Tumor (MeSH), Cell Proliferation (genetics), Cyclin-Dependent Kinase Inhibitor p21 (metabolism), Cytokines (genetics), Cytokines (metabolism), DNA Damage (drug effects), DNA Damage (genetics), DNA Damage (radiation effects), Doxorubicin (pharmacology), Humans (MeSH), Phosphorylation (MeSH), Promoter Regions, Genetic (genetics), Tumor Suppressor Protein p53 (metabolism), Ubiquitin-Activating Enzymes (metabolism), Ubiquitin-Conjugating Enzymes (metabolism), Ubiquitins (genetics), Ubiquitins (metabolism), Ultraviolet Rays (adverse effects), bcl-2-Associated X Protein (metabolism).
MESH :
- chemical , genetics : Cytokines, Ubiquitins.
- chemical , metabolism : Cyclin-Dependent Kinase Inhibitor p21, Cytokines, Tumor Suppressor Protein p53, Ubiquitin-Activating Enzymes, Ubiquitin-Conjugating Enzymes, Ubiquitins, bcl-2-Associated X Protein.
- adverse effects : Ultraviolet Rays.
- drug effects : DNA Damage.
- genetics : Carcinogenesis, Cell Proliferation, DNA Damage, Promoter Regions, Genetic.
- pathology : Carcinogenesis.
- chemical , pharmacology : Doxorubicin.
- radiation effects : DNA Damage.
- Acetylation, Cell Line, Tumor, Humans, Phosphorylation.

Abstract

p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced by DNA-damaging agents, such as ultraviolet and doxorubicin, which are known to induce p53. Here, we show that the genes encoding ISG15, UBE1L, UBCH8 and EFP, have the p53-responsive elements and their expression is induced in a p53-dependent fashion under DNA damage conditions. Furthermore, DNA damage induces ISG15 conjugation to p53 and this modification markedly enhances the binding of p53 to the promoters of its target genes (for example, CDKN1 and BAX) as well as of its own gene by promoting phosphorylation and acetylation, leading to suppression of cell growth and tumorigenesis. These findings establish a novel feedback circuit between p53 and ISG15-conjugating system for positive regulation of the tumour suppressive function of p53 under DNA damage conditions.

DOI: 10.1038/ncomms12513
PubMed: 27545325
PubMed Central: PMC4996943

Affiliations:

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Le document en format XML

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<author><name sortKey="Jeon, Young Joo" sort="Jeon, Young Joo" uniqKey="Jeon Y" first="Young Joo" last="Jeon">Young Joo Jeon</name>
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<author><name sortKey="Seol, Jae Hong" sort="Seol, Jae Hong" uniqKey="Seol J" first="Jae Hong" last="Seol">Jae Hong Seol</name>
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<author><name sortKey="Chung, Chin Ha" sort="Chung, Chin Ha" uniqKey="Chung C" first="Chin Ha" last="Chung">Chin Ha Chung</name>
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<country xml:lang="fr">Corée du Sud</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylation (MeSH)</term>
<term>Carcinogenesis (genetics)</term>
<term>Carcinogenesis (pathology)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Cell Proliferation (genetics)</term>
<term>Cyclin-Dependent Kinase Inhibitor p21 (metabolism)</term>
<term>Cytokines (genetics)</term>
<term>Cytokines (metabolism)</term>
<term>DNA Damage (drug effects)</term>
<term>DNA Damage (genetics)</term>
<term>DNA Damage (radiation effects)</term>
<term>Doxorubicin (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Tumor Suppressor Protein p53 (metabolism)</term>
<term>Ubiquitin-Activating Enzymes (metabolism)</term>
<term>Ubiquitin-Conjugating Enzymes (metabolism)</term>
<term>Ubiquitins (genetics)</term>
<term>Ubiquitins (metabolism)</term>
<term>Ultraviolet Rays (adverse effects)</term>
<term>bcl-2-Associated X Protein (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acétylation (MeSH)</term>
<term>Altération de l'ADN (effets des médicaments et des substances chimiques)</term>
<term>Altération de l'ADN (effets des radiations)</term>
<term>Altération de l'ADN (génétique)</term>
<term>Carcinogenèse (anatomopathologie)</term>
<term>Carcinogenèse (génétique)</term>
<term>Cytokines (génétique)</term>
<term>Cytokines (métabolisme)</term>
<term>Doxorubicine (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Inhibiteur p21 de kinase cycline-dépendante (métabolisme)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Prolifération cellulaire (génétique)</term>
<term>Protéine Bax (métabolisme)</term>
<term>Protéine p53 suppresseur de tumeur (métabolisme)</term>
<term>Rayons ultraviolets (effets indésirables)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Ubiquitin-activating enzymes (métabolisme)</term>
<term>Ubiquitin-conjugating enzymes (métabolisme)</term>
<term>Ubiquitines (génétique)</term>
<term>Ubiquitines (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term>
<term>Ubiquitins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin-Dependent Kinase Inhibitor p21</term>
<term>Cytokines</term>
<term>Tumor Suppressor Protein p53</term>
<term>Ubiquitin-Activating Enzymes</term>
<term>Ubiquitin-Conjugating Enzymes</term>
<term>Ubiquitins</term>
<term>bcl-2-Associated X Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Ultraviolet Rays</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinogenèse</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>DNA Damage</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Altération de l'ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Altération de l'ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Rayons ultraviolets</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term>
<term>Cell Proliferation</term>
<term>DNA Damage</term>
<term>Promoter Regions, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Altération de l'ADN</term>
<term>Carcinogenèse</term>
<term>Cytokines</term>
<term>Prolifération cellulaire</term>
<term>Régions promotrices (génétique)</term>
<term>Ubiquitines</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Inhibiteur p21 de kinase cycline-dépendante</term>
<term>Protéine Bax</term>
<term>Protéine p53 suppresseur de tumeur</term>
<term>Ubiquitin-activating enzymes</term>
<term>Ubiquitin-conjugating enzymes</term>
<term>Ubiquitines</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Doxorubicine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Doxorubicin</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>DNA Damage</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Acetylation</term>
<term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Acétylation</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Phosphorylation</term>
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<front><div type="abstract" xml:lang="en">p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced by DNA-damaging agents, such as ultraviolet and doxorubicin, which are known to induce p53. Here, we show that the genes encoding ISG15, UBE1L, UBCH8 and EFP, have the p53-responsive elements and their expression is induced in a p53-dependent fashion under DNA damage conditions. Furthermore, DNA damage induces ISG15 conjugation to p53 and this modification markedly enhances the binding of p53 to the promoters of its target genes (for example, CDKN1 and BAX) as well as of its own gene by promoting phosphorylation and acetylation, leading to suppression of cell growth and tumorigenesis. These findings establish a novel feedback circuit between p53 and ISG15-conjugating system for positive regulation of the tumour suppressive function of p53 under DNA damage conditions.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27545325</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<PubDate><Year>2016</Year>
<Month>08</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.</ArticleTitle>
<Pagination><MedlinePgn>12513</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms12513</ELocationID>
<Abstract><AbstractText>p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced by DNA-damaging agents, such as ultraviolet and doxorubicin, which are known to induce p53. Here, we show that the genes encoding ISG15, UBE1L, UBCH8 and EFP, have the p53-responsive elements and their expression is induced in a p53-dependent fashion under DNA damage conditions. Furthermore, DNA damage induces ISG15 conjugation to p53 and this modification markedly enhances the binding of p53 to the promoters of its target genes (for example, CDKN1 and BAX) as well as of its own gene by promoting phosphorylation and acetylation, leading to suppression of cell growth and tumorigenesis. These findings establish a novel feedback circuit between p53 and ISG15-conjugating system for positive regulation of the tumour suppressive function of p53 under DNA damage conditions.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Jong Ho</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Seung Wook</ForeName>
<Initials>SW</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Jung Mi</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ka</LastName>
<ForeName>Seung Hyeun</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Ji-Hoon</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kong</LastName>
<ForeName>Young-Yun</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeon</LastName>
<ForeName>Young Joo</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Institute of Medical Science, Chungnam National University School of Medicine, Daejon 34134, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seol</LastName>
<ForeName>Jae Hong</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chung</LastName>
<ForeName>Chin Ha</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>The 2nd Division of Natural Sciences, National Academy of Science, Seoul 06579, Korea.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>08</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
<NlmUniqueID>101528555</NlmUniqueID>
<ISSNLinking>2041-1723</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C494826">BAX protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050759">Cyclin-Dependent Kinase Inhibitor p21</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C495901">TP53 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016159">Tumor Suppressor Protein p53</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014452">Ubiquitins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051028">bcl-2-Associated X Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>60267-61-0</RegistryNumber>
<NameOfSubstance UI="C074034">ISG15 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>80168379AG</RegistryNumber>
<NameOfSubstance UI="D004317">Doxorubicin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.3.2.23</RegistryNumber>
<NameOfSubstance UI="C471622">UBE2L6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.3.2.23</RegistryNumber>
<NameOfSubstance UI="D044763">Ubiquitin-Conjugating Enzymes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 6.2.1.45</RegistryNumber>
<NameOfSubstance UI="C534879">UBA7 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 6.2.1.45</RegistryNumber>
<NameOfSubstance UI="D044764">Ubiquitin-Activating Enzymes</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000107" MajorTopicYN="N">Acetylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063646" MajorTopicYN="N">Carcinogenesis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050759" MajorTopicYN="N">Cyclin-Dependent Kinase Inhibitor p21</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004249" MajorTopicYN="N">DNA Damage</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004317" MajorTopicYN="N">Doxorubicin</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016159" MajorTopicYN="N">Tumor Suppressor Protein p53</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044764" MajorTopicYN="N">Ubiquitin-Activating Enzymes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044763" MajorTopicYN="N">Ubiquitin-Conjugating Enzymes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014452" MajorTopicYN="N">Ubiquitins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014466" MajorTopicYN="N">Ultraviolet Rays</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051028" MajorTopicYN="N">bcl-2-Associated X Protein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>03</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>07</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>8</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>8</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>9</Month>
<Day>5</Day>
<Hour>6</Hour>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Oncogene. 2001 May 31;20(25):3193-205</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11423969</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1992 Jul 2;358(6381):80-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1614537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2012 Sep;11(9):1968-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22752428</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 Jan;83(2):1147-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19004958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Immun. 2014 Jul-Aug;15(5):282-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24807690</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2002 Apr 1;11(7):799-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11929852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Jan 1;517(7532):89-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25307056</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2010 Dec 1;70(23):9875-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20935222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15623-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9861020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2006 Jan 15;66(2):921-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16424026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):211-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8552607</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2014 Jul 30;5(14):5808-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25071020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 1994 Mar 1;54(5):1169-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8118801</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Apr 30;458(7242):1127-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19407794</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Apr 30;279(18):18178-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14976209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2009 Jul 22;28(14):2100-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19536131</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2001 Mar;7(3):683-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11463392</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Cell Dev Biol. 2004 Apr;15(2):237-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15209384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Sep 28;337(6102):1684-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22859821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Feb 17;281(7):4334-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16407192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2012 Nov 28;31(23):4441-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23092970</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1992 Jul 2;358(6381):15-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1614522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2259-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14982997</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2002 Dec;22(24):8601-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12446779</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2014;13(14):2200-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24844324</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2006 Jun;13(6):1037-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16601749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10096-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12114540</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1997 Feb 7;88(3):323-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9039259</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Breast Cancer Res. 2008;10(4):R58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18627608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2012 Jul;122(7):2622-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22706304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2009 Jul 16;28(28):2606-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19430494</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Cancer. 2006 May 22;94(10):1465-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16641915</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1987 Aug 15;262(23):11315-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2440890</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2010 May;1802(5):485-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20153823</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging (Albany NY). 2009 May 07;1(5):490-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20157532</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1993 Jul;7(7A):1126-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8319905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 1999 Sep 1;59(17):4375-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10485486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2001 Feb 1;20(3):362-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11157743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 1999 Dec 13;18(53):7637-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10618703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 1992 Apr;1(1):45-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1301998</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Feb 17;281(7):3989-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16352599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2001 Feb;2(2):139-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11258706</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2014 May 22;54(4):626-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24768535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1995 Jan 27;80(2):293-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7834749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Cancer. 2000 Mar 15;85(6):871-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10709110</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2010 Jun 11;38(5):722-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20542004</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2011 Feb 18;144(4):566-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21335238</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1999 Nov 15;18(22):6462-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10562558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 Jul 9;118(1):83-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15242646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Jan 19;282(3):1797-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17098746</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2008 Dec;7(12 ):3780-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19074853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17227866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11891284</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1991 Oct 15;147(8):2617-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1717569</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Rep. 2010 Jan;23(1):11-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19956859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Cell Res. 2013 Mar 10;319(5):612-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23291318</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2002 May;1(4):369-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12086851</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2008 Apr;7(4):905-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18413804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2007 May;117(5):1370-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17446929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2004 Nov;24(21):9592-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15485925</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Cell Biol. 2003 Apr;15(2):164-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12648672</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Mol Med. 2013 Apr 12;45:e18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23579383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1999 Nov 15;18(22):6455-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10562557</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1997 Aug 22;90(4):595-606</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9288740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2008 May;9(5):402-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18431400</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Mar 22;277(12 ):9976-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11788588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2015 Mar 9;27(3):354-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25759021</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Cancer. 2015 Nov 10;15:886</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26555296</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Corée du Sud</li>
</country>
<region><li>Région capitale de Séoul</li>
</region>
<settlement><li>Séoul</li>
</settlement>
<orgName><li>Université nationale de Séoul</li>
</orgName>
</list>
<tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Jong Ho" sort="Park, Jong Ho" uniqKey="Park J" first="Jong Ho" last="Park">Jong Ho Park</name>
</region>
<name sortKey="Chung, Chin Ha" sort="Chung, Chin Ha" uniqKey="Chung C" first="Chin Ha" last="Chung">Chin Ha Chung</name>
<name sortKey="Chung, Chin Ha" sort="Chung, Chin Ha" uniqKey="Chung C" first="Chin Ha" last="Chung">Chin Ha Chung</name>
<name sortKey="Jeon, Young Joo" sort="Jeon, Young Joo" uniqKey="Jeon Y" first="Young Joo" last="Jeon">Young Joo Jeon</name>
<name sortKey="Ka, Seung Hyeun" sort="Ka, Seung Hyeun" uniqKey="Ka S" first="Seung Hyeun" last="Ka">Seung Hyeun Ka</name>
<name sortKey="Kim, Ji Hoon" sort="Kim, Ji Hoon" uniqKey="Kim J" first="Ji-Hoon" last="Kim">Ji-Hoon Kim</name>
<name sortKey="Kong, Young Yun" sort="Kong, Young Yun" uniqKey="Kong Y" first="Young-Yun" last="Kong">Young-Yun Kong</name>
<name sortKey="Park, Jung Mi" sort="Park, Jung Mi" uniqKey="Park J" first="Jung Mi" last="Park">Jung Mi Park</name>
<name sortKey="Seol, Jae Hong" sort="Seol, Jae Hong" uniqKey="Seol J" first="Jae Hong" last="Seol">Jae Hong Seol</name>
<name sortKey="Yang, Seung Wook" sort="Yang, Seung Wook" uniqKey="Yang S" first="Seung Wook" last="Yang">Seung Wook Yang</name>
</country>
</tree>
</affiliations>
</record>

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Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.

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